The Accidental Vaccine

THE OVERLOOK

By Tom Clavin

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Usually, I write about American history, or this week, given that Friday is the 95^th anniversary of an event, a column would be connected in some way to Valentine’s Day. But we’re heading to Great Britain and a story involving a vaccine.

Alexander Fleming was the seventh of eight children of a Scottish hill farmer. His country upbringing in southwestern Scotland sharpened his capacities for observation and appreciation of the natural world at an early age. He began his elementary schooling at Loudoun Moor and then moved on to a larger school at Darvel before enrolling in Kilmarnock Academy in 1894. In 1895, he moved to London to live with his elder brother Thomas (who worked as an oculist) and completed his basic education at Regent Street Polytechnic.

After working as a London shipping clerk, Fleming began his medical studies at St. Mary’s Hospital School. He won the 1908 gold medal as top medical student at the University of London. At first, he planned to become a surgeon, but a temporary position in the laboratories of the Inoculation Department at St. Mary’s Hospital convinced him that his future lay in the new field of bacteriology. There he came under the influence of bacteriologist and immunologist Sir Almroth Wright, whose ideas of vaccine therapy seemed to offer a revolutionary direction in medical treatment.

Between 1909 and 1914 Fleming established a successful private practice as a venereologist, and in 1915 he married Sarah Marion McElroy, an Irish nurse. Their son, Robert, born in 1924, would follow his father into medicine. Fleming was one of the first doctors in Great Britain to administer arsphenamine, a drug effective against syphilis that was discovered by German scientist Paul Ehrlich in 1910.

During World War I, Fleming had a commission in the Royal Army Medical Corps and worked as a bacteriologist studying wound infections in a laboratory that Wright had set up in a military hospital in France. There he demonstrated that the use of strong antiseptics on wounds did more harm than good and recommended that the wounds simply be kept clean with a mild saline solution.

Fleming returned to St. Mary’s after the war and was promoted to assistant director of the Inoculation Department. In November 1921, he discovered lysozyme, an enzyme present in body fluids such as saliva and tears that has a mild antiseptic effect. That was the first of his major discoveries. It came about when he had a cold and a drop of his nasal mucus fell onto a culture plate of bacteria. Realizing that his mucus might affect bacterial growth, he mixed the mucus into the culture and a few weeks later saw signs of the bacteria having been dissolved. Fleming’s study of lysozyme, which he considered his best work as a scientist, was a significant contribution to the understanding of how the body fights infection.

On September 3, 1928, shortly after his appointment as professor of bacteriology, Fleming noticed that a culture plate of Staphylococcus aureus he had been working on had become contaminated by a fungus. A mold, later identified as Penicillium notatum (now classified as P. chrysogenum), had inhibited the growth of the bacteria. He at first called the substance “mould juice” and then “penicillin,” after the mold that produced it.

Fleming decided to investigate further, because he thought that he had found an enzyme more potent than lysozyme. In fact, it was not an enzyme but an antibiotic—one of the first to be discovered. By the time Fleming had established that, he was interested in penicillin for itself. Very much the lone researcher with an eye for the unusual, Fleming had the freedom to pursue anything that interested him. Working with two young researchers, Fleming learned that penicillin had clinical potential, both as a topical antiseptic and as an injectable antibiotic, if it could be isolated and purified. He announced the discovery of penicillin on February 14, 1929.

Penicillin eventually came into use during World War II as the result of the work of a team of scientists led by Howard Florey at the University of Oxford. Though Florey, his coworker Ernst Chain, and Fleming shared the 1945 Nobel Prize, their relationship was clouded by the issue of who should gain the most credit for penicillin. Fleming’s role was emphasized by the press because of the uniqueness of his chance discovery and his greater willingness to speak to journalists.

Fleming was knighted in 1944. In 1949 his first wife, who had changed her name to Sareen, died. In 1953, two years prior to his death, Fleming married the microbiologist Amalia Coutsouris-Voureka, who had been involved in the Greek resistance movement during World War II and had been Fleming’s colleague since 1946, when she enrolled at St. Mary’s Hospital on a scholarship.

For the last decade of his life, Fleming was feted universally for his discovery of penicillin and acted as a world ambassador for medicine and science. Initially a shy uncommunicative man and a poor lecturer, he blossomed under the attention he received, becoming one of the world’s best-known scientists.

Over the decades, millions of lives have been saved by penicillin and related vaccines. Dos it work for everyone? No. Some people are even allergic to it. But the benefits have made a big difference in public health. One can’t help thinking of the Covid vaccine. It did not work for everyone and there have been some adverse reactions. But it is hard to argue with numbers. As of February 1, 2025, there have been 1,221,863 deaths from Covid-19 in the U.S. Almost 850,000 of those came during the first two years of the pandemic, then the vaccine and its boosters took hold. So far this year: 3315 deaths. What other explanation can there be for such a dramatic reduction in deaths – Covid-19 just petered out by itself?

Tom Clavin is the bestselling author/co-author of 25 books, including Bandit Heaven and, with Bob Drury, Throne of Grace. To purchase copies, please go to your local bookstore or to Bookshop.org, Amazon.com, BN.com, or tomclavin.com.